2021年11月10日星期三

What is the reason for "10 men and 9 hemorrhoids"? Research: about 100 scholars analyzed the data of 950000 people to clarify the pathogenesis of hemorrhoids

From: China Biotechnology Network

Hemorrhoids are the most common anal diseases in clinic. According to the location of hemorrhoids, they can be divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids. Anyway, hemorrhoids affect most people in the world. So some people say "10 men, 9 hemorrhoids, 10 women, 10 hemorrhoids". This hidden inconvenience will also affect the quality of life when it is serious. But so far, there is no clue about the pathogenesis and potential risk factors of hemorrhoids.

In the study published in gut on April 23 Beijing time, an international research team of nearly 100 people led by Monash University in Australia analyzed the genomic data of nearly 950000 people for the first time and determined the cause of hemorrhoids. This study provides important insights for a better understanding of the pathogenesis of hemorrhoids.

Hemorrhoids lower rectal anal pad pathological hypertrophy, pain, pruritus, sometimes bleeding, limiting daily activities. Most patients with hemorrhoids can solve this problem through over-the-counter drugs, but more serious patients need surgery.

The risk factors of hemorrhoids are considered to be sedentary, obesity, too little dietary fiber intake, too long toilet time, tension during defecation, too much strength and so on. But few people consider this problem in genetics.

In this study, the research team conducted a genome-wide correlation study (GWA) meta-analysis of 218920 patients with hemorrhoids and 725213 healthy people based on the British biological bank and the European cluster study. A variety of genetic relationships between hemorrhoids and other properties were analyzed, and a variety of genetics of hemorrhoids were found.

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