Four generations of a family infected with "weird disease" intestinal polyps are the bane-Guangzhou Daily
Source: Guangzhou Daily 2009-9-17
Text/Reporter Weng Shuxian
Correspondent: Jian Wenyang
Four generations of people have dark spots on their mouths and faces. Both the mother and grandfather will not live to 35 years old, and they have bloody stools and abdominal pain before death; the son is now over 30, and he had intussusception-induced intestinal necrosis three years ago. The one-meter-long small intestine still has bleeding in the stool. What worries the family is that the fourth-generation grandson who is only over 4 years old also has needle-sized black spots on his mouth. Every time he defecates, hemorrhoid-like things will appear. Anus falls out... A family living in a remote country has little knowledge, but when they talk about this "weird disease", they feel fear and despair, and even regard it as an ominous "family curse."
In the eyes of experts, the "code" of this "magic curse" is not difficult to decipher. The first two generations were killed because they were not treated in time until the intestinal polyps were too large and too large, causing complications or cancer; now, As long as the third and fourth generations with the same symptoms are actively treated, they will not fall into the “family doom” that cannot survive 35 years old again.
"Family Curse": Both previous two generations will not survive 35 years
Qin Changchun, a 31-year-old Hunan guy, has dark spots on his lips. He has a little blood in the stool every time he feces in adulthood. In addition, his body has no other abnormalities. Until 3 years ago, he had abdominal pain. He was found in the hospital with intussusception, which caused part of the small intestine necrosis to be surgically removed. During the operation, the doctor discovered that there were many polyps in his small intestine, so he could only select some large polyps and remove them first. Later, when the doctor performed a colonoscopy on him, he discovered that his large intestine had many polyps of different sizes, and finally diagnosed that these polyps and dark spots were family genetic diseases.
This discovery reminded Qin Changchun of his mother and grandfather who had never lived beyond 35. They also had dark spots on their faces, and they often had blood in the stool and abdominal pain before death. He vaguely felt that he might not escape the fate of 35 years old.
However, when he was in his early 30s, he was lamenting that he had "lack of time" and was glad that this strange family disease was only passed on to the eldest son and the eldest daughter. He, his mother and grandfather were both the "boss" in the family, and his eldest son's face Black spots have never appeared, and the family's doom may end in his generation. Unexpectedly, his 4-year-old second son now has needle-sized black spots on his mouth, and hemorrhoid-like things fall out of the anus every time he defecates...
A few days ago, Qin Changchun and his son were diagnosed with "Pigmented Polyp Syndrome" at the Sixth Affiliated Hospital of Sun Yat-sen University.
Intestinal polyps: can cause complications or cancer
Each generation has a 50% genetic probability
From the perspective of Qin Changchun's family genetic history, each generation has a 50% probability of inheritance. It was just a coincidence that "only the eldest son was passed on to the eldest daughter" before, and his second son "Zhong Zhao" is also reasonable.
Although there is no specific medicine for this disease, the disease itself is not terrible. As long as symptomatic treatment, 35 years old is not the limit of life for such patients. As for Qin Changchun’s ancestors who did not live to 35 years old, it may be due to the limitations of the local medical level and their own economic reasons, they did not have the conditions to find a specialist hospital for diagnosis and timely treatment, resulting in excessive and large intestinal polyps, causing intussusception, intestinal obstruction, Complications such as gastrointestinal bleeding may even cause polyps to become cancerous and ultimately life-threatening.
Living beyond 35 is not a problem
Li Chujun told reporters that due to the advancement of inspection methods and the enhancement of people's awareness of health care, more and more patients with intestinal polyps are found clinically, which is a good thing. Like Qin Changchun, as long as he actively cooperates with treatment, it is not a problem to break the fate of similar patients in the family who will not survive 35 years.
At present, considering that some polyps in Qin Changchun’s large intestine are "large" and are of a type that proliferates quickly and can cause cancer, the doctor recommended that he remove the entire large intestine and assessed that he might have diarrhea in the short term after surgery, but after a period of recovery It can return to normal after treatment.
However, Qin Changchun's son was discovered early, and after reasonable treatment at the appropriate time, as long as he regularly checks to prevent recurrence, block cancer or induce complications, the prognosis may be better than his father.
People with a family history of intestinal polyps should undergo regular colonoscopy. Once signs of this “family curse” are found, they should be removed as soon as possible and reviewed regularly to prevent recurrence, and resolutely block the way polyps worsen and become cancerous.
Intestinal polyps how to know early
Li Chujun pointed out that pigmented polyp syndrome has certain obvious characteristics. In addition to symptoms such as abdominal pain and blood in the stool like ordinary intestinal polyposis patients, the skin and mucous membranes may have dark brown pigment spots, which are more common in the lips, buccal mucosa, and perioral area. The skin and the skin of the palms of the hands and feet. However, for most ordinary intestinal polyps patients, there are basically no other "clues" to follow in the early stage except for symptoms such as abdominal pain, diarrhea, blood in the stool, or constipation that are easily misdiagnosed as gastrointestinal infection, indigestion or hemorrhoids.
Although intestinal polyps are not equal to malignant tumors, there are not a few patients with intestinal cancer caused by their malignant transformation. Therefore, Li Chujun suggests that people can follow the following principles to decide whether to perform electronic colonoscopy and related resection:
1. Even if the person over 40 years old has never had any abnormal symptoms, he/she should take the initiative to do the first colonoscopy health check to rule out abnormalities;
2. If one of your close relatives finds intestinal polyps or intestinal cancer, they should have an early colonoscopy health check;
3. Blood in the stool or abnormal mucus in the stool, in addition to considering hemorrhoids or enteritis, it is best to do colonoscopy to rule out abnormal intestinal polyps;
4. When polyps are found, it is best to eradicate them regardless of their size. Staying in the body may become a "dark wound" that will become malignant without knowing when;
5. The cut polyps should be sent for biopsy to find out whether there are signs of malignant change; after that, they should be reviewed regularly, and re-excision should be done once they recur.
Recommendation: light diet and drink less alcohol
Li Chujun also specially reminded that although the cause of gastrointestinal polyps is not yet clear, studies have shown that it is related to chronic inflammation, mechanical irritation, constipation and excessive daily meat eating in related parts. Therefore, he suggested that people should eat moderate amounts of meat. It is best to keep a light diet, eat more fresh vegetables and fruits, eat less spicy foods and drink less, and develop good bowel habits, and try to make the gastrointestinal tract less uncomfortable. Necessary stimulation and keep it open, paying attention to the above-mentioned "inconspicuous details" will help avoid polyposis.